Table of Contents:

Part I: Introduction

Hematopoiesis and Bone Marrow Histology
Bone Marrow Examination and Techniques
Bone Marrow Reporting
Overview of Constitutional and Acquired Bone Marrow Disorders

Part II: Anemia

Overview of Anemia

SECTION 1: ACQUIRED ANEMIAS
Iron Deficiency Anemia
Autoimmune Hemolytic Anemias
Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn
Microangiopathic Hemolytic Anemia
Megaloblastic Anemia
Acquired Nonneoplastic Sideroblastic Anemia
Alcoholism-Associated Anemia
Anemia in the Elderly
Copper Deficiency-Associated Anemia
Acquired Red Cell Aplasia
Transient Erythroblastopenia of Childhood
Parvovirus-Induced Red Cell Aplasia
Paroxysmal Nocturnal Hemoglobinuria
Acquired Aplastic Anemia

SECTION 2: CONSTITUTIONAL ANEMIAS
Thalassemia
Sickle Cell Anemia
Pyruvate Kinase Deficiency
Hereditary Spherocytosis
Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis
Diamond-Blackfan Anemia
Fanconi Anemia
Congenital Dyserythropoietic Anemia
Congenital Sideroblastic Anemia
Congenital Megaloblastic Anemia

Part III: Erythrocytosis

SECTION 1: CONSTITUTIONAL

Congenital Erythrocytosis

SECTION 2: ACQUIRED

Acquired Erythrocytosis

Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow

Overview of Benign Leukocyte Disorders in Blood and Bone Marrow
Pancytopenia
Neutropenia
Neutrophilia
Monocytosis
Eosinophilia
Basophilia
Lymphocytosis
Lymphopenia, Constitutional and Acquired
Plasmacytosis of Bone Marrow
Hematogones in Bone Marrow
Lymphoid Aggregates in Bone Marrow
Granulomas in Bone Marrow

Part V: Constitutional Granulocytic Disorders

SECTION 1: CONSTITUTIONAL NEUTROPENIAS

Severe Congenital Neutropenia and Cyclic Neutropenia
Shwachman-Diamond Syndrome
Chediak-Higashi Syndrome
Myelokathexis in WHIM Syndrome

SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES

Pelger-Huet Anomaly
MYH9-Related Disorders
Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

Part VI: Megakaryocytic Disorders

Overview of Megakaryocytic Disorders

SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

Immune-Mediated Thrombocytopenia
Hemolytic-Uremic Syndrome
Thrombotic Thrombocytopenic Purpura
Pregnancy-Associated Thrombocytopenia

SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

Thrombocytopenia Absent Radius Syndrome
Congenital Amegakaryocytic Thrombocytopenia
Gray Platelet Syndrome
Wiskott-Aldrich Syndrome-Related Disorders
Congenital Thrombotic Thrombocytopenic Purpura

SECTION 3: THROMBOCYTOSIS

Thrombocytosis

Part VII: Infection

Overview of Infection
Hantavirus Pulmonary Syndrome
Human Immunodeficiency Virus
Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)
Parvovirus B19 Infection
Bacterial Infections, Blood and Bone Marrow Features
Fungal Infections, Blood and Bone Marrow Features
Helminthic Infections
Malaria
Other Protozoan Infections

Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions

Overview and Classification of Hemophagocytic Disorders in Bone Marrow
Hematologic Manifestations of Collagen Vascular Disorders
Hematologic Manifestations of Chronic Renal Disorders
Lysosomal Storage Diseases With Predominantly Histiocytic Storage
Other Pregnancy-Associated Hematologic Disorders
Gelatinous Transformation and Other Bone Marrow Stromal Disorders
Crystals in Bone Marrow
Bone Abnormalities in Bone Marrow Specimens

Part IX: Myeloid Neoplasms

Overview and Classification of Myeloid Neoplasms
Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow
Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia

SECTION 1: MYELOPROLIFERATIVE NEOPLASMS

Overview of Myeloproliferative Neoplasms
Chronic Myelogenous Leukemia, BCR/ABL1+
Chronic Neutrophilic Leukemia
Polycythemia Vera
Primary Myelofibrosis
Essential Thrombocythemia
Chronic Eosinophilic Leukemia, Not Otherwise Specified
Systemic Mastocytosis
Mast Cell Leukemia
Myeloproliferative Neoplasm, Unclassifiable

SECTION 2: MYELOID AND LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB, AND FGFR1

Myeloid and Lymphoid Neoplasms With PDGFRA Rearrangement
Myeloid Neoplasms With PDGRFB Rearrangments
Myeloid and Lymphoid Neoplasms With FGFR1 Abnormalities

SECTION 3: MYELODYSPLASTIC & MYELOPROLIFERATIVE NEOPLASMS

Overview of Myelodysplastic/Myeloproliferative Neoplasms
Chronic Myelomonocytic Leukemia
Atypical Chronic Myeloid Leukemia, BCR/ABL1-
Juvenile Myelomonocytic Leukemia
RARS-T
Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable

SECTION 4: MYELODYSPLASTIC SYNDROMES

Overview and Classification of Myelodysplastic Syndromes
Myelodysplasia With Single Lineage Dysplasia
Myelodysplasia With Ring Sideroblasts
Myelodysplasia With Multilineage Dysplasia
Myelodysplasia With Increased Blasts
Myelodysplastic Syndrome With Isolated del(5q)
Myelodysplastic Syndrome, Unclassifiable
Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)

SECTION 5: ACUTE MYELOID LEUKEMIA

Overview of Acute Myeloid Leukemia
Familial AML/MDS
Acute Myeloid Leukemia With t(8;21)(q22;q22), RUNX1-RUNX1T1
Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB-MYH11
Acute Promyelocytic Leukemia With t(15;17)(q22;q21), PML-RARA
Acute Promyelocytic Leukemia With Variant RARA Rearrangement
Acute Myeloid Leukemia With t(9;11)(p22;q23), MLLT3-MLL
Additional Genetic Subtypes of Acute Myeloid Leukemia, Including t(6;9), inv(3), t(1;22), Mutated NPM1, Mutated CEBPA
Acute Myeloid Leukemia With Myelodysplasia- Related Changes
Therapy-Related Myeloid Neoplasms
Acute Myeloid Leukemia With Minimal Differentiation
Acute Myeloid Leukemia Without Maturation
Acute Myeloid Leukemia With Maturation
Acute Myelomonocytic Leukemia
Acute Monoblastic and Monocytic Leukemia
Acute Erythroid Leukemia
Acute Megakaryoblastic Leukemia
Acute Basophilic Leukemia
Acute Panmyelosis With Myelofibrosis
Myeloid Proliferations Related to Down Syndrome
Blastic Plasmacytoid Dendritic Cell Neoplasm

Part X: Acute Leukemias of Ambiguous Lineage

Acute Undifferentiated Leukemia
Mixed Phenotype Acute Leukemia

Part XI: Lymphoid Neoplasms

Overview of Lymphoid Neoplasms
Protocol for the Examination of Specimens from Patients With Non-Hodgkin Lymphoma/Lymphoid Neoplasms

SECTION 1: B-PRECURSOR NEOPLASMS

B-Lymphoblastic Leukemia
Novel Genetic Subtypes of B-Lymphoblastic Leukemia

SECTION 2: T-PRECURSOR NEOPLASMS

T-Lymphoblastic Leukemia/Lymphoma
ETP-ALL

SECTION 3: MATURE B-CELL NEOPLASMS

Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas
Monoclonal B Lymphocytes
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
B-Cell Prolymphocytic Leukemia
Splenic B-Cell Marginal Zone Lymphoma
Hairy Cell Leukemia
Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant
Lymphoplasmacytic Lymphoma
Gamma Heavy Chain Disease
Monoclonal Gammopathy of Undetermined Significance
Plasma Cell Myeloma
Burkitt Leukemia/Lymphoma
Mantle Cell Lymphoma in Blood and Bone Marrow
Follicular Cell Lymphoma in Blood and Bone Marrow
Marginal Zone Lymphoma in Blood and Bone Marrow
Large Cell Lymphoma in Blood and Bone Marrow
Other B-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 4: MATURE T/NK-CELL NEOPLASMS

Overview and Classification of Mature T/NK-Cell Neoplasms
T-Cell Prolymphocytic Leukemia
T-Cell Large Granular Lymphocytic Leukemia
Chronic Lymphoproliferative Disorder of NK Cells
Aggressive NK-Cell Leukemia
Adult T-Cell Leukemia
Mycosis Fungoides/Sézary Syndrome
Anaplastic Large Cell Lymphoma in Blood and Bone Marrow
Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow

SECTION 5: HODGKIN LYMPHOMA IN BONE MARROW

Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes
Protocol for the Examination of Specimens from Patients With Hodgkin Lymphoma

Part XII: Other Neoplasms Involving Bone Marrow

Langerhans Cell Histiocytosis in Bone Marrow
Hemophagocytic Disorders
Posttransplant Lymphoproliferative Disorders in Bone Marrow
Metastatic Carcinoma and Sarcoma