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The book documents the status of the art of the actual knowledge of multiple aspects related to gastric cancer. Although it has been edited by a surgeon, it takes inside the awareness that surgery is only one ring of the complex chain of the different items of this disease. The first parts of the text are facing epidemiology, molecular biology, genetics and the relationships with Helicobacter pylori infection. Then, after evaluating specific pathological aspects and problems related with modern endoscopy and endo-ultrasonography, different methods of treatments are examined. Multimodality treatment targeted on each single patient's and tumor's features represents the actual gold standard, while genetic therapy should be considered as the future goal of research worldwide. At the moment, improvement of early diagnosis and development of endoscopic resection techniques (EMR, ESD), early detection of responders to neoadjuvant chemotherapy in advanced cancers and preoperative detection through genomic profiling of patients with high risk of lymph node metastasis in order to modulate the extent of nodal dissection are the goals of multidisciplinary teams active in reference centers.
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